Grace Tiao talks about her work at the Broad Institute, as part of the methods development team for gnomAD, and shares her thoughts on genetic medicine.

The TGMI Team – Grace Tiao

We have become much better at making genetic diagnoses. But how good are we at answering the questions about prognosis that such diagnoses lead to? And how can we do better?

Prognosis not just diagnosis

#TGMIFriday in 2017
Looking back on the past year of #TGMIFriday, the most popular posts all talk about some of the basic issues that the TGMI is trying to address

A year in #TGMIFriday posts

Matthew Hurles
TGMI team member Matthew Hurles talks about his involvement in the DDD, DECIPHER and TGMI, and the problems that still need to be solved in genetic medicine.

The TGMI Team – Matthew Hurles

Not all issues in genetic medicine are scientific or medical challenges. Sometimes it’s all about communication and the way we share information.

Communication in genetic medicine

Fiona Cunningham talks about tools for annotating variation data, and the importance of having good foundational resources for use in genetic medicine.

The TGMI Team – Fiona Cunningham

VUS - very unhelpful statement
The mismanagement of Variants of Uncertain Significance (VUS) is a big problem in genetic medicine. Causing harms and lawsuits. Why does it occur?

VUS – Very Unhelpful Statement

Shawn Yost talks about his role on the TGMI team, and the importance of standardising transcripts and annotations.

The TGMI Team – Shawn Yost

information sharing
Sharing genetic information is essential for the success of genetic medicine. But the ultimate goal is sharing meaning.

Sharing genetic information